The AW109SP GrandNew G-HEMZ, foreground, and AW109E Power G-RSCU are respectively operated by the Derby Leicestershire and Rutland Air Ambulance from East Midlands Airport and the Warwickshire and Northamptonshire Air Ambulance from Coventry Airport.

The Thames Valley Air Ambulance is operated by Babcock MCS Onshore, formerly Bond Aviation Services. This was the initial H135 used for HEMS in the UK.

Specialist Aviation Services delivered this AW169 to the Essex and Hertfordshire Air Ambulance in July 2017.

First to use the AW169 for HEMS in the UK in 2016 was the Kent Surrey and Sussex Air Ambulance.

The Airbus Helicopters H145 has entered service with several HEMS operators in the UK including the Yorkshire Air Ambulance, which has two aircraft.